|
KMID : 0357119930150020147
|
|
Korean Journal of Immunology
1993 Volume.15 No. 2 p.147 ~ p.153
|
|
|
Endogenous Interferon α/β Produced by Lipid A-Stimulated Macrophages enhanced Phagocytic Activity of Mouse Macrophages
|
|
Kim Joong-Gon
|
|
|
Abstract
|
|
|
|
Previous study has demonstrated that lipid A could markedly enhance the FcR-dependent phagocytic activity of mouse macrophages. In this report, the mechanism responsible for the enhancement of phagocytic activity of lipid A -stimulated macrophages was elucidated. Macrophages at the higher density showed higher phagocytic activity compared to those at the lower density, indicating that the cytokine(s) produced by macrophages should be involved in up-regulating the phagocytosis. Studies with the monokines revealed that IL-1 did not show any significant effect on the phagocytosis, and TNF increased the phagocytic activity of macrophages at the high concentration but slightly increased at low concentration. IFN-a/Q enhanced the phagocytic activity. Addition of anti-IFN-a/19 antibody markedly reduced the phagocytic activity of unstimulated macrophages as well as lipid A-stimulated macrophages. These findings indicate that endogenous IFN-a//3 produced by lipid A-stimulated macrophages enhanced phagocytic activity of mouse macrophage through autostimulatory effect.
|
|
|
KEYWORD
|
|
|
Macrophage, Lipid A, Interferon α/β, Phagocytosis
|
|
|
FullTexts / Linksout information
|
|
|
|
|
|
Listed journal information
|
|
 
|